Deficient tonic GABAergic conductance and synaptic balance in the 1 Fragile - X Syndrome Amygdala
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چکیده
Deficient tonic GABAergic conductance and synaptic balance in the 1 Fragile-X Syndrome Amygdala 2 Brandon S. Martin, Joshua G. Corbin, and Molly M. Huntsman 3 4 Center for Neuroscience Research, Children’s National Medical Center, Washington 5 DC, 20010 USA; Interdisciplinary Program in Neuroscience, Georgetown University 6 Medical Center, Washington DC, 20057 USA; Department of Pharmaceutical Sciences, 7 Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of 8 Pediatrics, School of Medicine, University of Colorado, Anschutz Medical Campus, 9 Aurora, CO 80045 10 11 Running title: Altered tonic inhibition in fragile X syndrome 12 Pages: 42, Tables: 2, Figures: 5 13 14 15 *Correspondence should be addressed to: 16 Dr. Molly M. Huntsman 17 Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and 18 Pharmaceutical Sciences and the Department of Pediatrics School of Medicine, 19 University of Colorado | Anschutz Medical Campus 20 Aurora, CO 80045 21 Phone: (303) 724-7456 22 Fax: (303) 724-2637 23 Email: [email protected] 24 25 26 27 28 Articles in PresS. J Neurophysiol (May 21, 2014). doi:10.1152/jn.00597.2013
منابع مشابه
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala.
Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are increasingly linked to imbalances in excitation and inhibition (E/I) as well as dysfunction in GABAergic transmission in a number of brain regions including the amygdala. However, the link between E/I imbalance and GABAergic transmission deficits in the FXS amygdala is poo...
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